Mice, Knockout Concept

subject area of

• 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice  Journal Articles
• 4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques  Journal Articles
• 4D intravital imaging identifies platelets as the predominant cellular procoagulant surface in a mouse hemostasis model  Journal Articles
• Ahnak-knockout mice show susceptibility toBartonella henselaeinfection because of CD4+ T cell inactivation and decreased cytokine secretion  Journal Articles
• Fgl2deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice  Journal Articles
• In vivoimaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome  Journal Articles
• A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology  Journal Articles
• A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent  Journal Articles
• A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo  Journal Articles
• A critical role for IL‐15 in TLR‐mediated innate antiviral immunity against genital HSV‐2 infection  Journal Articles
• A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion  Journal Articles
• A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1  Journal Articles
• A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions  Journal Articles
• A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke  Journal Articles
• A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis  Journal Articles
• A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease  Journal Articles
• A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease  Journal Articles
• A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources  Journal Articles
• A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice  Journal Articles
• ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer  Journal Articles
• AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise  Journal Articles
• AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging  Journal Articles
• AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue  Journal Articles
• AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism  Journal Articles
• AMPK mediates energetic stress‐induced liver GDF15  Journal Articles
• AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation  Journal Articles
• AMP‐activated protein kinase is required for exercise‐induced peroxisome proliferator‐activated receptor γ co‐activator 1α translocation to subsarcolemmal mitochondria in skeletal muscle  Journal Articles
• AP-2α knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis  Journal Articles
• AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle  Journal Articles
• AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development  Journal Articles
• AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal  Journal Articles
• ARMMs as a versatile platform for intracellular delivery of macromolecules  Journal Articles
• Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice  Journal Articles
• Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice  Journal Articles
• Abnormal neural precursor cell regulation in the early postnatal Fragile X mouse hippocampus  Journal Articles
• Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy  Journal Articles
• Absence of p21CIP Rescues Myogenic Progenitor Cell Proliferative and Regenerative Capacity in Foxk1 Null Mice  Journal Articles
• Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2  Journal Articles
• Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin  Journal Articles
• Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity  Journal Articles
• Activation of CD8 T Cells by Mycobacterial Vaccination Protects against Pulmonary Tuberculosis in the Absence of CD4 T Cells  Journal Articles
• Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models  Journal Articles
• Activation of autophagy by globular adiponectin is required for muscle differentiation  Journal Articles
• Activation of the Unfolded Protein Response Occurs at All Stages of Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice  Journal Articles
• Adaptive immune responses fail to provide protection against genital HSV‐2 infection in the absence of IL‐15  Journal Articles
• Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract.  Journal Articles
• Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function  Journal Articles
• Adipose‐specific ATGL ablation reduces burn injury‐induced metabolic derangements in mice  Journal Articles
• Adjunctive β2‐agonists reverse neuromuscular involvement in murine Pompe disease  Journal Articles
• Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis  Journal Articles
• Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway  Journal Articles
• Akt isoform specific effects in ovarian cancer progression  Journal Articles
• Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling  Journal Articles
• Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice.  Journal Articles
• Alternatively Activated Macrophages Drive Browning of White Adipose Tissue in Burns  Journal Articles
• Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice  Journal Articles
• Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis  Journal Articles
• Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis  Journal Articles
• An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses  Journal Articles
• An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice  Conferences
• An investigation of scavenger receptor A mediated leukocyte binding to polyanionic and uncharged polymer hydrogels  Journal Articles
• Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression  Journal Articles
• Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy  Journal Articles
• Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway  Journal Articles
• Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes  Journal Articles
• Antifibrotic Role of αB-Crystallin Inhibition in Pleural and Subpleural Fibrosis  Journal Articles
• Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes  Journal Articles
• Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages  Journal Articles
• Ascorbic acid synthesis due to l-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells  Journal Articles
• Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin  Journal Articles
• Assessment of Requirements for IL-15 and IFN Regulatory Factors in Uterine NK Cell Differentiation and Function During Pregnancy  Journal Articles
• Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice  Journal Articles
• Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model  Journal Articles
• Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model  Journal Articles
• Astrocyte‐mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome  Journal Articles
• Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase  Journal Articles
• B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity  Journal Articles
• B Cells Are Not Involved in the Regulation of Adenoviral TGF-β1– or Bleomycin-Induced Lung Fibrosis in Mice  Journal Articles
• B7RP-1 Is Not Required for the Generation of Th2 Responses in a Model of Allergic Airway Inflammation but Is Essential for the Induction of Inhalation Tolerance  Journal Articles
• BMP Receptor ALK3 Controls Collecting System Development  Journal Articles
• BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis  Journal Articles
• Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1  Journal Articles
• Behavioral abnormalities in synapsin II knockout mice implicate a causal factor in schizophrenia  Journal Articles
• Behavioral effects of infection with interferon-gamma adenovector  Journal Articles
• Bi-phasic gliosis drives neuropathology in a Sandhoff disease mouse model  Journal Articles
• Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”  Journal Articles
• Brain Microbial Populations in HIV/AIDS: α-Proteobacteria Predominate Independent of Host Immune Status  Journal Articles
• Bruton’s tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK  Journal Articles
• CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy  Journal Articles
• CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria  Journal Articles
• CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen  Journal Articles
• CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor– and Complement Receptor 3–Dependent Mechanisms  Journal Articles
• CD4⁺ T‐cell‐mediated anti‐tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis  Journal Articles
• CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells  Journal Articles
• CXCL9 Contributes to Antimicrobial Protection of the Gut during Citrobacter rodentium Infection Independent of Chemokine-Receptor Signaling  Journal Articles
• CXCR6 by increasing retention of memory CD8⁺ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer  Journal Articles
• Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF-κB Signaling  Journal Articles
• Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy  Journal Articles
• Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells  Journal Articles
• Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells  Journal Articles
• Cell‐specific effects of nitric oxide on the efficiency and frequency of long distance contractions in murine colon  Journal Articles
• Ceramide Is Responsible for the Failure of Compensatory Nerve Sprouting in Apolipoprotein E Knock-Out Mice  Journal Articles
• Characterization and IL-15 dependence of NK cells in humanized mice  Journal Articles
• Characterization of Retinal Microvascular Complications and the Effects of Endoplasmic Reticulum Stress in Mouse Models of Diabetic Atherosclerosis  Journal Articles
• Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr-/- Macrophages  Journal Articles
• Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia  Journal Articles
• Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion  Journal Articles
• Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure  Journal Articles
• Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice  Journal Articles
• Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance  Journal Articles
• Cigarette Smoke Primes the Pulmonary Environment to IL-1α/CXCR-2–Dependent Nontypeable Haemophilus influenzae–Exacerbated Neutrophilia in Mice  Journal Articles
• Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-β production  Journal Articles
• Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis inSmad3knockout mice  Journal Articles
• Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-α signaling  Journal Articles
• Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice  Journal Articles
• Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation  Journal Articles
• Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly  Journal Articles
• Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.  Journal Articles
• Class A Scavenger Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity  Journal Articles
• Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival  Journal Articles
• Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating  Journal Articles
• Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle  Journal Articles
• Comprehensive Plasma Metabolomic Analyses of Atherosclerotic Progression Reveal Alterations in Glycerophospholipid and Sphingolipid Metabolism in Apolipoprotein E-deficient Mice  Journal Articles
• Conditional deletion of AP-2β in the cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma  Journal Articles
• Control of Pathogenic CD4 T Cells and Lethal Immunopathology by Signaling Immunoadaptor DAP12 during Influenza Infection  Journal Articles
• Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise  Journal Articles
• Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3  Journal Articles
• Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors  Journal Articles
• Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection  Journal Articles
• Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice  Journal Articles
• Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells  Journal Articles
• Current Concepts in Mechanisms of Emphysema  Journal Articles
• Cutting Edge: Cytokine-Dependent Abortion in CBA × DBA/2 Mice Is Mediated by the Procoagulant fgl2 Prothombinase  Journal Articles
• Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 CompositecisElements  Journal Articles
• DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants  Journal Articles
• Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis  Journal Articles
• Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance  Journal Articles
• Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts  Journal Articles
• Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice  Journal Articles
• Defining the roles of perforin, Fas/FasL, and tumour necrosis factor   in T cell induced mucosal damage in the mouse intestine  Journal Articles
• Delayed but effective induction of mucosal memory immune responses against genital HSV-2 in the absence of secondary lymphoid organs  Journal Articles
• Deleting Rac1 improves vertebral bone quality and resistance to fracture in a murine ovariectomy model  Journal Articles
• Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr−/− Mice  Journal Articles
• Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype  Journal Articles
• Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity  Journal Articles
• Deletion of tumor necrosis factor-α ameliorates neurodegeneration in Sandhoff disease mice  Journal Articles
• Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T  Journal Articles
• Developmental expression of FMRP in the astrocyte lineage: Implications for fragile X syndrome  Journal Articles
• Developmental expression of the neuroligins and neurexins in fragile X mice  Journal Articles
• Developmental regulation of O 2 sensing in neonatal adrenal chromaffin cells from wild-type and NADPH-oxidase-deficient mice  Journal Articles
• Diacylglycerol Kinase Delta Promotes Lipogenesis  Journal Articles
• Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice  Journal Articles
• Dietary Protective Effects Against Hepatocellular Carcinoma Development in Mdr2-/- Knockout Mice.  Journal Articles
• Dietary Supplementation With Methionine and Homocysteine Promotes Early Atherosclerosis but Not Plaque Rupture in ApoE-Deficient Mice  Journal Articles
• Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis  Journal Articles
• Differential Regulation of DAP12 and Molecules Associated with DAP12 during Host Responses to Mycobacterial Infection  Journal Articles
• Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation  Journal Articles
• Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.  Journal Articles
• Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression  Journal Articles
• Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice  Journal Articles
• Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax  Journal Articles
• Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes  Journal Articles
• Dramatically Different Phenotypes in Mouse Models of Human Tay-Sachs and Sandhoff Diseases  Journal Articles
• Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes.  Journal Articles
• ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes  Journal Articles
• ERM is required for transcriptional control of the spermatogonial stem cell niche  Journal Articles
• Effect of Leptin on Vascular Calcification in Apolipoprotein E–Deficient Mice  Journal Articles
• Effects of Obesity-Associated Chronic Inflammation on Peripheral Blood Immunophenotype Are Not Mediated by TNF in Female C57BL/6J Mice  Journal Articles
• Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits  Conferences
• Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice  Journal Articles
• Endogenous interleukin‐6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice  Journal Articles
• Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis  Journal Articles
• Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria  Journal Articles
• Enhanced Rate of Nerve Regeneration and Directional Errors After Sciatic Nerve Injury in Receptor Protein Tyrosine Phosphatase ς Knock-Out Mice  Journal Articles
• Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662  Journal Articles
• Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4  Journal Articles
• Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine  Journal Articles
• Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut  Journal Articles
• Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis  Journal Articles
• Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression  Journal Articles
• Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity  Journal Articles
• ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival  Journal Articles
• Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression  Journal Articles
• Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway  Journal Articles
• Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase  Journal Articles
• Ethylenecarbodiimide-Fixed Donor Splenocyte Infusions Differentially Target Direct and Indirect Pathways of Allorecognition for Induction of Transplant Tolerance  Journal Articles
• Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis  Journal Articles
• Evidence for the role of AMPK in regulating PGC‐1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue  Journal Articles
• Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells  Journal Articles
• Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours  Journal Articles
• Expression of the Th1 Chemokine IFN-γ-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice  Journal Articles
• Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction.  Journal Articles
• Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia  Journal Articles
• FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis  Journal Articles
• Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi  Journal Articles
• Factors influencing therapeutic efficacy and the host immune response to helper‐dependent adenoviral gene therapy in hemophilia A mice  Journal Articles
• Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI  Journal Articles
• Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis  Journal Articles
• FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice  Journal Articles
• Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help  Journal Articles
• Follistatin promotes adipocyte differentiation, browning, and energy metabolism  Journal Articles
• Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression  Journal Articles
• Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice  Journal Articles
• Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.  Journal Articles
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Journal Articles
• Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy  Journal Articles
• Further evidence for a role of tumor CD200 expression in breast cancer metastasis: decreased metastasis in CD200R1KO mice or using CD200-silenced EMT6  Journal Articles
• GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.  Journal Articles
• GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis  Journal Articles
• Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice  Journal Articles
• Galectin-3 impairs calcium transients and β-cell function  Journal Articles
• Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice  Journal Articles
• Generation of experimental allergic airways inflammation in the absence of draining lymph nodes  Journal Articles
• Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance  Journal Articles
• Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis  Journal Articles
• Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity  Journal Articles
• Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells  Journal Articles
• Glycogen Synthase Kinase 3α Deficiency Attenuates Atherosclerosis and Hepatic Steatosis in High Fat Diet–Fed Low Density Lipoprotein Receptor–Deficient Mice  Journal Articles
• Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis  Journal Articles
• GnRH antagonist associates with less adiposity and reduced characteristics of metabolic syndrome and atherosclerosis compared with orchiectomy and GnRH agonist in a preclinical mouse model1Contributed equally and share first authorship.  Journal Articles
• Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma  Journal Articles
• Granulocyte Macrophage Colony–Stimulating Factor–Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4  Journal Articles
• Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury  Journal Articles
• Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: A comparative study in gene‐deficient mice  Journal Articles
• Gut hormones: emerging role in immune activation and inflammation  Journal Articles
• HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner  Journal Articles
• HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis  Journal Articles
• Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling  Journal Articles
• Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity  Journal Articles
• Heparan sulfate: Antithrombotic or not?  Journal Articles
• Hepatic Apoptosis Postburn Is Mediated by C-Jun N-Terminal Kinase 2  Journal Articles
• Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse  Journal Articles
• Hepatic Lipase Deficiency Delays Atherosclerosis, Myocardial Infarction, and Cardiac Dysfunction and Extends Lifespan in SR-BI/Apolipoprotein E Double Knockout Mice  Journal Articles
• Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice  Journal Articles
• Heterogeneity of the immune response to adenovirus‐mediated factor VIII gene therapy in different inbred hemophilic mouse strains  Journal Articles
• Heterophilic Binding of L1 on Unmyelinated Sensory Axons Mediates Schwann Cell Adhesion and Is Required for Axonal Survival  Journal Articles
• High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists  Journal Articles
• High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation  Journal Articles
• High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2  Journal Articles
• Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes  Journal Articles
• Histidine-Rich Glycoprotein Modulates the Toxic Effects of High-Dose Polyphosphate in Mice  Journal Articles
• Homer modulates NFAT-dependent signaling during muscle differentiation  Journal Articles
• Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice  Journal Articles
• Hyperglycemia promotes insulin-independent ovarian tumor growth  Journal Articles
• Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo  Journal Articles
• Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling  Journal Articles
• IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII  Journal Articles
• IFN-γ-Induced Chemokines Synergize with Pertussis Toxin to Promote T Cell Entry to the Central Nervous System  Journal Articles
• IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization  Journal Articles
• IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes  Journal Articles
• IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut  Journal Articles
• IL-15 Can Signal via IL-15Rα, JNK, and NF-κB To Drive RANTES Production by Myeloid Cells  Journal Articles
• IL-17 Production by γδ+ T Cells Is Critical for Inducing Th17 Responses in the Female Genital Tract and Regulated by Estradiol and Microbiota  Journal Articles
• IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion  Journal Articles
• IL-5 contributes to worm expulsion and muscle hypercontractility in a primaryT. spiralisinfection  Journal Articles
• IL-6 Signal From the Bone Marrow is Required for the Browning of White Adipose Tissue Post Burn Injury  Journal Articles
• IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.  Journal Articles
• IL-6 is not essential for exercise-induced increases in glucose uptake  Journal Articles
• IL‐12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure  Journal Articles
• Identification of periplakin as a major regulator of lung injury and repair in mice  Journal Articles
• Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis  Journal Articles
• Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection  Journal Articles
• Immunohistochemical detection of N-homocysteinylated proteins in humans and mice  Journal Articles
• Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses  Journal Articles
• Impact of a complex nutraceutical supplement on primary tumour formation and metastasis in Trp53+/– cancer-prone mice  Journal Articles
• Impaired c-src activation and motility defects in PEA3-null fibroblasts  Journal Articles
• Increased Cell Proliferations and Neurogenesis in the Hippocampal Dentate Gyrus of Ahnak Deficient Mice  Journal Articles
• Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling  Journal Articles
• Increased Small Bowel Epithelial Turnover in Interleukin-1 Receptor Knockout Mice  Journal Articles
• Induction of Innate Immunity against Herpes Simplex Virus Type 2 Infection via Local Delivery of Toll-Like Receptor Ligands Correlates with Beta Interferon Production  Journal Articles
• Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1  Journal Articles
• Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions  Journal Articles
• Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis  Journal Articles
• Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology  Journal Articles
• Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation  Journal Articles
• Inhalation of a harmless antigen (ovalbumin) elicits immune activation but divergent immunoglobulin and cytokine activities in mice  Journal Articles
• Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis  Journal Articles
• Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release  Journal Articles
• Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan  Journal Articles
• Innate Immune Processes Are Sufficient for Driving Cigarette Smoke–Induced Inflammation in Mice  Journal Articles
• Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase  Journal Articles
• Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome  Journal Articles
• Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice  Journal Articles
• Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition  Journal Articles
• Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4–Deficient Mice  Journal Articles
• Interleukin 13 and Serotonin: Linking the Immune and Endocrine Systems in Murine Models of Intestinal Inflammation  Journal Articles
• Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice  Journal Articles
• Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function  Journal Articles
• Interleukin-13–Dependent Expression of Matrix Metalloproteinase-12 Is Required for the Development of Airway Eosinophilia in Mice  Journal Articles
• Interleukin-15 and NK1.1⁺Cells Provide Innate Protection against AcuteSalmonella entericaSerovar Typhimurium Infection in the Gut and in Systemic Tissues  Journal Articles
• Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-γ  Journal Articles
• Interleukin-15 is required for maximal lipopolysaccharide-induced abortion  Journal Articles
• Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase  Journal Articles
• Interleukin‐15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes  Journal Articles
• Interleukin‐5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections  Journal Articles
• Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice forms  Journal Articles
• Intrinsic expression of viperin regulates thermogenesis in adipose tissues  Journal Articles
• Investigating the Role of Endothelial Glycogen Synthase Kinase3α/β in Atherogenesis in Low Density Lipoprotein Receptor Knockout Mice  Journal Articles
• Knockdown of spinal metabotropic glutamate receptor 1 (mGluR₁) alleviates pain and restores opioid efficacy after nerve injury in rats  Journal Articles
• LPS‐Induced Occult Loss in Mice Requires FGL2  Journal Articles
• LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML  Journal Articles
• Lactobacillus rhamnosus Ingestion Promotes Innate Host Defense in an Enteric Parasitic Infection  Journal Articles
• Late onset Tay–Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system  Journal Articles
• Lens-Specific Expression of TGF-β Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3  Journal Articles
• Leukocyte urokinase plasminogen activator receptor and PSGL1 play a role in endogenous arterial fibrinolysis  Journal Articles
• Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development  Journal Articles
• Leukotrienes and the brain  Journal Articles
• Lifelong memory responses perpetuate humoral T H 2 immunity and anaphylaxis in food allergy  Journal Articles
• Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain–containing inositol 5-phosphatase (SHIP-1)  Journal Articles
• Lipidomic analysis of skeletal muscle tissues of p53 knockout mice by nUPLC-ESI-MS/MS  Journal Articles
• Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis  Journal Articles
• Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity1  Journal Articles
• Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia  Journal Articles
• Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E–Deficient Mice  Journal Articles
• Loss of T cells influences sex differences in behavior and brain structure  Journal Articles
• Loss of T cells influences sex differences in stress-related gene expression  Journal Articles
• Loss of class I MHC function alters behavior and stress reactivity  Journal Articles
• Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration  Journal Articles
• Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability  Journal Articles
• Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer  Journal Articles
• Lysyl Oxidase–Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1–induced Pulmonary Fibrosis  Journal Articles
• MARCO Is Required for TLR2- and Nod2-Mediated Responses to Streptococcus pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx  Journal Articles
• MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-β-Induced EMT in the Lens  Journal Articles
• MUC1/episialin: a critical barrier in the female reproductive tract  Journal Articles
• Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance  Journal Articles
• Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression  Journal Articles
• Macrophages are a significant source of type 1 cytokines during mycobacterial infection  Journal Articles
• Mas receptors in modulating relaxation induced by perivascular adipose tissue  Journal Articles
• Matrix Metalloproteinase-9–Null Mice Are Resistant to TGF-β–Induced Anterior Subcapsular Cataract Formation  Journal Articles
• Mechanical Strain-Induced RhoA Activation Requires NADPH Oxidase-Mediated ROS Generation in Caveolae  Journal Articles
• Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision  Journal Articles
• Mechanisms of innate immune activation by gluten peptide p31-43 in mice  Journal Articles
• Membrane Perturbation-Associated Ca ²⁺ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry  Journal Articles
• Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• Mice with deleted multimerin 1 and α-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1  Journal Articles
• MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx  Journal Articles
• MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia  Journal Articles
• MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis  Journal Articles
• Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects  Journal Articles
• Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice  Journal Articles
• Molecules in focus Transforming growth factor-beta (TGF-β)  Journal Articles
• Mouse phenogenomics, toolbox for functional annotation of human genome  Journal Articles
• MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot–Marie–Tooth disease type 1B  Journal Articles
• Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury  Journal Articles
• Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection  Journal Articles
• Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization  Journal Articles
• Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs  Journal Articles
• Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid  Journal Articles
• Muscle‐specific AMPK β1β2‐null mice display a myopathy due to loss of capillary density in nonpostural muscles  Journal Articles
• Mutations in the Chromatin Regulator Gene BRPF1 Cause Syndromic Intellectual Disability and Deficient Histone Acetylation  Journal Articles
• Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse  Journal Articles
• Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.  Journal Articles
• Myocardial Infarction Following Atherosclerosis in Murine Models  Journal Articles
• Myostatin inhibition therapy for insulin-deficient type 1 diabetes  Journal Articles
• NADPH oxidase is an O ₂ sensor in airway chemoreceptors: Evidence from K ⁺ current modulation in wild-type and oxidase-deficient mice  Journal Articles
• NK Cells Play a Critical Protective Role in Host Defense against Acute ExtracellularStaphylococcus aureusBacterial Infection in the Lung  Journal Articles
• NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection  Journal Articles
• NKT-cell help to B lymphocytes can occur independently of cognate interaction  Journal Articles
• NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase  Journal Articles
• NLRP3 deficiency exacerbates enterovirus infection in mice  Journal Articles
• NLRP3 inflammasome mediates white adipose tissue browning after burn  Journal Articles
• NLRP3 knockout enhances immune infiltration and inflammatory responses and improves survival in a burn sepsis model  Journal Articles
• NOD1 Activators Link Innate Immunity to Insulin Resistance  Journal Articles
• NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice  Journal Articles
• Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection  Journal Articles
• Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture  Journal Articles
• Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice  Journal Articles
• Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse  Journal Articles
• Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P  Journal Articles
• Neutralization of LPS or blockage of TLR4 signaling prevents stress-triggered fetal loss in murine pregnancy  Journal Articles
• Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function  Journal Articles
• New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection  Journal Articles
• Normalization of obesity-associated insulin resistance through immunotherapy  Journal Articles
• Novel function of Oncostatin M as a potent tumour‐promoting agent in lung  Journal Articles
• ORIGINAL ARTICLE: LPS‐Induced Murine Abortions Require C5 but not C3, and are Prevented by Upregulating Expression of the CD200 Tolerance Signaling Molecule  Journal Articles
• Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure  Journal Articles
• On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier  Journal Articles
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Journal Articles
• Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod‐induced psoriasis‐like inflammation  Journal Articles
• Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6  Journal Articles
• Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma  Journal Articles
• Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression  Journal Articles
• Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model  Journal Articles
• Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2  Journal Articles
• Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression  Journal Articles
• Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse  Journal Articles
• P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus.  Journal Articles
• PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice  Journal Articles
• PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle  Journal Articles
• PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice  Journal Articles
• PPARδ activation attenuates hepatic steatosis in Ldlr mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity  Journal Articles
• PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function  Journal Articles
• Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia  Journal Articles
• Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo  Journal Articles
• Pathogenesis of Murine Experimental Allergic Rhinitis: A Study of Local and Systemic Consequences of IL-5 Deficiency  Journal Articles
• Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.  Journal Articles
• Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure  Journal Articles
• Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca ²⁺ Release and Cardiac Contractility, Independently of L-Type Ca ²⁺ Current  Journal Articles
• Physiological Modulation of Intestinal Motility by Enteric Dopaminergic Neurons and the D₂Receptor: Analysis of Dopamine Receptor Expression, Location, Development, and Function in Wild-Type and Knock-Out Mice  Journal Articles
• Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor  Journal Articles
• Plasma fibronectin supports hemostasis and regulates thrombosis  Journal Articles
• Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis  Journal Articles
• Platelet PECAM-1 inhibits thrombus formation in vivo  Journal Articles
• Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells  Journal Articles
• Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration  Journal Articles
• Postbiotics engage IRF4 in adipocytes to promote sex‐dependent changes in blood glucose during obesity  Journal Articles
• Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice  Journal Articles
• Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb  Journal Articles
• Prenatal stress enhances severity of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring via inflammatory pathways  Journal Articles
• Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination  Journal Articles
• Progressive Loss of Retinal Ganglion Cells in Activating Protein-2β Neural Crest Cell Knockout Mice  Journal Articles
• Protection by CD4 or CD8 T Cells against PulmonaryMycobacterium bovisBacillus Calmette-Guérin Infection  Journal Articles
• Protein tyrosine phosphatase σ‐deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system  Journal Articles
• Prothrombotic Effects of Hyperhomocysteinemia and Hypercholesterolemia in ApoE-Deficient Mice  Journal Articles
• Proximal Gut Mucosal Epithelial Homeostasis in Aged IL-1 Type I Receptor Knockout Mice after Starvation  Journal Articles
• Psychosis pathways converge via D2High dopamine receptors  Journal Articles
• Pulmonary Expression of Oncostatin M (OSM) Promotes Inducible BALT Formation Independently of IL-6, Despite a Role for IL-6 in OSM-Driven Pulmonary Inflammation  Journal Articles
• Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS^−/−mice and human smokers  Journal Articles
• Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model  Journal Articles
• RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice  Journal Articles
• RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice  Journal Articles
• Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise  Journal Articles
• Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity  Journal Articles
• Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice  Journal Articles
• Reciprocal actions of interleukin‐6 and brain‐derived neurotrophic factor on rat and mouse primary sensory neurons  Journal Articles
• Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice  Journal Articles
• Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression  Journal Articles
• Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in AdolescentShank3Null Mutant Mice  Journal Articles
• Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism  Journal Articles
• Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance  Journal Articles
• Reduction of GAG storage in MPS II mouse model following implantation of encapsulated recombinant myoblasts  Journal Articles
• Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain  Journal Articles
• Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway  Journal Articles
• Regulation of glycolysis and the Warburg effect in wound healing  Journal Articles
• Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity  Journal Articles
• Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice  Journal Articles
• Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts Is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-Specific MicroRNA 122  Journal Articles
• Replication-Defective Adenovirus Infection ReducesHelicobacter felisColonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner  Journal Articles
• Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis  Journal Articles
• Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis  Journal Articles
• Role of Ets transcription factors in mammary gland development and oncogenesis.  Journal Articles
• Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction  Journal Articles
• Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells  Journal Articles
• Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus  Journal Articles
• Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine  Journal Articles
• Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study  Journal Articles
• S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3  Journal Articles
• SMAD3-dependent and -independent pathways in glomerular injury associated with experimental glomerulonephritis  Journal Articles
• SR-BI in Bone Marrow Derived Cells Protects Mice from Diet Induced Coronary Artery Atherosclerosis and Myocardial Infarction  Journal Articles
• SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells  Journal Articles
• STAT-6 Is an Absolute Requirement for Murine Rejection of Hymenolepis diminuta  Journal Articles
• Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis  Journal Articles
• Salicylate improves macrophage cholesterol homeostasis via activation of Ampk  Journal Articles
• Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1  Journal Articles
• Salsalate reduces atherosclerosis through AMPKβ1 in mice  Journal Articles
• Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease  Journal Articles
• Scavenger Receptor Class B Type I–Mediated Protection Against Atherosclerosis in LDL Receptor–Negative Mice Involves Its Expression in Bone Marrow–Derived Cells  Journal Articles
• Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: recent lessons from genetically manipulated mice.  Journal Articles
• Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen  Journal Articles
• Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α‐chain CDR3 loop  Journal Articles
• Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis  Journal Articles
• Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy  Journal Articles
• Sex-Specific Differences in an ApoE−/−:Ins2+/Akita Mouse Model of Accelerated Atherosclerosis  Journal Articles
• Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice  Journal Articles
• Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation  Journal Articles
• Skeletal Muscle Mitochondrial Morphology Negatively Affected in Mice Lacking Xin  Journal Articles
• Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis  Journal Articles
• Socs1 Deficiency Enhances Hepatic Insulin Signaling  Journal Articles
• Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice  Journal Articles
• Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR  Journal Articles
• Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion  Journal Articles
• Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin  Journal Articles
• Synapsin II knockout mice show sensorimotor gating and behavioural abnormalities similar to those in the phencyclidine-induced preclinical animal model of schizophrenia  Journal Articles
• Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis  Journal Articles
• Syndecan-1 in the Mouse Parietal Peritoneum Microcirculation in Inflammation  Journal Articles
• Synergistic Effects of cAMP- and Calcium-Mediated Amylase Secretion in Isolated Pancreatic Acini from Cystic Fibrosis Mice  Journal Articles
• T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes  Journal Articles
• TACAN Is an Ion Channel Involved in Sensing Mechanical Pain  Journal Articles
• TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells  Journal Articles
• TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease  Journal Articles
• TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium  Journal Articles
• TGF-  receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung  Journal Articles
• TGF-β and Smad3 Signaling Link Inflammation to Chronic Fibrogenesis  Journal Articles
• TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae  Journal Articles
• TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut  Journal Articles
• Targeted Deletion ofAP-2α Leads to Disruption in Corneal Epithelial Cell Integrity and Defects in the Corneal Stroma  Journal Articles
• Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages  Journal Articles
• Targeting C3a/C5a receptors inhibits human mesangial cell proliferation and alleviates immunoglobulin A nephropathy in mice  Journal Articles
• Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development  Journal Articles
• Testing NF-kappa B1-p50 antibody specificity using knockout mice.  Journal Articles
• The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages  Journal Articles
• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase  Journal Articles
• The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses  Journal Articles
• The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation  Journal Articles
• The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice  Journal Articles
• The Effects of Hyperglycemia on Early Endothelial Activation and the Initiation of Atherosclerosis  Journal Articles
• The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis  Journal Articles
• The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity  Journal Articles
• The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice  Journal Articles
• The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels  Journal Articles
• The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938  Journal Articles
• The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice  Journal Articles
• The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter  Journal Articles
• The aryl hydrocarbon receptor suppresses cigarette-smoke-induced oxidative stress in association with dioxin response element (DRE)-independent regulation of sulfiredoxin 1  Journal Articles
• The caveolin-1 regulated protein follistatin protects against diabetic kidney disease  Journal Articles
• The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK  Journal Articles
• The complement factor C5a receptor is upregulated in NFL−/− mouse motor neurons  Journal Articles
• The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction  Journal Articles
• The fibrinogen but not the Factor VIII content of transfused plasma determines its effectiveness at reducing bleeding in coagulopathic mice  Journal Articles
• The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury  Journal Articles
• The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies  Journal Articles
• The neuropeptide Y Y1 receptor mediates NPY‐induced inhibition of the gonadotrope axis under poor metabolic conditions  Journal Articles
• The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis  Journal Articles
• The role of AMP‐activated protein kinase in the expression of the dystrophin‐associated protein complex in skeletal muscle  Journal Articles
• The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis  Journal Articles
• The role of sphingosine kinase 2 in alcoholic liver disease  Journal Articles
• The role of the CCR1 receptor in the inflammatory response to tobacco smoke in a mouse model  Journal Articles
• The small heat‐shock protein αB‐crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis  Journal Articles
• The thrombospondin-1 receptor CD36 is an important mediator of ovarian angiogenesis and folliculogenesis  Journal Articles
• Three-dimensional computed tomography imaging in an animal model of emphysema  Journal Articles
• Thrombospondin‐1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor‐related protein‐1 (LRP‐1)  Journal Articles
• Tie2 protects the vasculature against thrombus formation in systemic inflammation  Journal Articles
• Titin is a Target of Matrix Metalloproteinase-2  Journal Articles
• Toll-like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis.  Journal Articles
• Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector  Journal Articles
• Transforming Growth Factor-β Regulates House Dust Mite–induced Allergic Airway Inflammation but Not Airway Remodeling  Journal Articles
• Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner  Journal Articles
• Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP  Journal Articles
• Tumor necrosis factor drives increased splenic monopoiesis in old mice  Journal Articles
• Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity  Journal Articles
• Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity  Journal Articles
• Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells  Journal Articles
• Type I interferon signalling is not required for the induction of endotoxin tolerance  Journal Articles
• Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation  Journal Articles
• VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit  Journal Articles
• VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents  Journal Articles
• Weight Loss–Associated Induction of Peroxisome Proliferator–Activated Receptor-α and Peroxisome Proliferator–Activated Receptor-γ Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice  Journal Articles
• Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity  Journal Articles
• Xin‐deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality  Journal Articles
• YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth  Journal Articles
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