Journal article
GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin‐induced pulmonary fibrosis
Abstract
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been associated with fibrotic lung disease, although exactly how they modulate this process remains unclear. Here we investigated the role of GRP78, the main UPR regulator, in an experimental model of lung injury and fibrosis. Grp78(+/-) , Chop(-/-) and wild type C57BL6/J mice were exposed to bleomycin by oropharyngeal intubation and lungs were examined at days 7 and …
Authors
Ayaub EA; Kolb PS; Mohammed-Ali Z; Tat V; Murphy J; Bellaye P-S; Shimbori C; Boivin FJ; Lai R; Lynn EG
Journal
The Journal of Pathology, Vol. 239, No. 4, pp. 411–425
Publisher
Wiley
Publication Date
August 2016
DOI
10.1002/path.4738
ISSN
0022-3417