AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation Academic Article uri icon

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abstract

  • Key Points AMPK-ACC signaling in platelets is a key mechanism regulating primary hemostasis and arterial thrombosis. AMPK-ACC signaling controls collagen-induced TXA2 generation and dense granule release by modulating platelet phospholipid content.

authors

  • Lepropre, Sophie
  • Kautbally, Shakeel
  • Octave, Marie
  • Ginion, Audrey
  • Onselaer, Marie-Blanche
  • Steinberg, Gregory
  • Kemp, Bruce E
  • Hego, Alexandre
  • Wéra, Odile
  • Brouns, Sanne
  • Swieringa, Frauke
  • Giera, Martin
  • Darley-Usmar, Victor M
  • Ambroise, Jérôme
  • Guigas, Bruno
  • Heemskerk, Johan
  • Bertrand, Luc
  • Oury, Cécile
  • Beauloye, Christophe
  • Horman, Sandrine

publication date

  • September 13, 2018

published in