AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation Journal Articles

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abstract

Key PointsAMPK-ACC signaling in platelets is a key mechanism regulating primary hemostasis and arterial thrombosis. AMPK-ACC signaling controls collagen-induced TXA2 generation and dense granule release by modulating platelet phospholipid content.

authors

Lepropre, Sophie
Kautbally, Shakeel
Octave, Marie
Ginion, Audrey
Onselaer, Marie-Blanche
Steinberg, Gregory
Kemp, Bruce E
Hego, Alexandre
Wéra, Odile
Brouns, Sanne
Swieringa, Frauke
Giera, Martin
Darley-Usmar, Victor M
Ambroise, Jérôme
Guigas, Bruno
Heemskerk, Johan
Bertrand, Luc
Oury, Cécile
Beauloye, Christophe
Horman, Sandrine

status

published

publication date

September 13, 2018

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
AMP-Activated Protein Kinases (MeSH)
Acetyl-CoA Carboxylase (MeSH)
Animals (MeSH)
Blood Platelets (MeSH)
Gene Knock-In Techniques (MeSH)
Immunology (Science Metrix)
Mice (MeSH)
Mice, Knockout (MeSH)
Phosphorylation (MeSH)
Signal Transduction (MeSH)
Thrombosis (MeSH)

published in

Blood Journal