A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice Journal Articles

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abstract

Key PointsThe D′D3 domains of VWF are sufficient to stabilize FVIII in vivo. The prolongation of VWF D′D3 survival in vivo by Fc fusion elevates FVIII levels in the setting of VWF but not FVIII deficiency.

authors

Yee, Andrew
Gildersleeve, Robert D
Gu, Shufang
Kretz, Colin
McGee, Beth M
Carr, Keisha M
Pipe, Steven W
Ginsburg, David

status

published

publication date

July 17, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Factor VIII (MeSH)
Humans (MeSH)
Immunoglobulin Fc Fragments (MeSH)
Immunoglobulin G (MeSH)
Immunology (Science Metrix)
Mice (MeSH)
Mice, 129 Strain (MeSH)
Mice, Inbred C57BL (MeSH)
Mice, Knockout (MeSH)
Multiprotein Complexes (MeSH)
Peptide Fragments (MeSH)
Protein Interaction Domains and Motifs (MeSH)
Protein Stability (MeSH)
Recombinant Fusion Proteins (MeSH)
von Willebrand Factor (MeSH)

published in

Blood Journal