A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice Academic Article uri icon

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abstract

  • Key Points The D′D3 domains of VWF are sufficient to stabilize FVIII in vivo. The prolongation of VWF D′D3 survival in vivo by Fc fusion elevates FVIII levels in the setting of VWF but not FVIII deficiency.

authors

  • Yee, Andrew
  • Gildersleeve, Robert D
  • Gu, Shufang
  • Kretz, Colin
  • McGee, Beth M
  • Carr, Keisha M
  • Pipe, Steven W
  • Ginsburg, David

publication date

  • July 17, 2014

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