Journal article
SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells
Abstract
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent studies showed that overexpression of the transcription factor SREBP-1 induces glomerulosclerosis. TGFβ1 is a key profibrotic mediator of glomerulosclerosis, but whether SREBP-1 regulates its effects is unknown. In kidney mesangial cells and in vivo, TGFβ1 activates SREBP-1. This requires SCAP, S1P, and PI3K/Akt signaling, but is independent of Smad3. Activation of the …
Authors
Chen G; Wang T; Uttarwar L; vanKrieken R; Li R; Chen X; Gao B; Ghayur A; Margetts P; Krepinsky JC
Journal
Journal of Molecular Cell Biology, Vol. 6, No. 6, pp. 516–530
Publisher
Oxford University Press (OUP)
Publication Date
December 1, 2014
DOI
10.1093/jmcb/mju041
ISSN
1674-2788