PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle Academic Article uri icon

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abstract

  • Nedd4-1 (neural precursor cell-expressed developmentally down-regulated 4-1) mediates skeletal muscle atrophy. We identify PDLIM7 as a novel Nedd4-1 substrate, binding Nedd4-1 WW domains via its PY motif and co-localizing with Nedd4-1 in myotubes. The interaction results in PDLIM7 ubiquitination and may underlie Nedd4-1-mediated muscle wasting.

authors

  • D'Cruz, Robert
  • Plant, Pamela J
  • Pablo, Lesley A
  • Lin, Shouzhe
  • Chackowicz, Joshua
  • Correa, Judy
  • Bain, James
  • Batt, Jane

publication date

  • February 1, 2016

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