Journal article
Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion
Abstract
ABSTRACT: Somatic mutations in the TET2 gene occur more frequently with age, imparting an intrinsic hematopoietic stem cells (HSCs) advantage and contributing to a phenomenon termed clonal hematopoiesis of indeterminate potential (CHIP). Individuals with TET2-mutant CHIP have a higher risk of developing myeloid neoplasms and other aging-related conditions. Despite its role in unhealthy aging, the extrinsic mechanisms driving TET2-mutant CHIP …
Authors
Quin C; DeJong EN; McNaughton AJM; Buttigieg MM; Basrai S; Abelson S; Larché MJ; Rauh MJ; Bowdish DME
Journal
Blood Advances, Vol. 8, No. 15, pp. 4169–4180
Publisher
American Society of Hematology
Publication Date
August 13, 2024
DOI
10.1182/bloodadvances.2023011833
ISSN
2473-9529