Journal article
Transforming Growth Factor-β Regulates House Dust Mite–induced Allergic Airway Inflammation but Not Airway Remodeling
Abstract
RATIONALE: It is now believed that both chronic airway inflammation and remodeling contribute significantly to airway dysfunction and clinical symptoms in allergic asthma. Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma.
OBJECTIVES: We investigated the role of …
Authors
Fattouh R; Midence NG; Arias K; Johnson JR; Walker TD; Goncharova S; Souza KP; Gregory RC; Lonning S; Gauldie J
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 177, No. 6, pp. 593–603
Publisher
American Thoracic Society
Publication Date
March 15, 2008
DOI
10.1164/rccm.200706-958oc
ISSN
1073-449X