Journal article
Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine
Abstract
Background: The translation of preclinically promising novel tuberculosis vaccines to ultimate human applications has been challenged by the lack of animal models with an immune system equivalent to the human immune system in its genetic diversity and level of susceptibility to tuberculosis.
Methods: We have developed a humanized mice (Hu-mice) tuberculosis model system to investigate the clinical relevance of a novel virus-vectored (VV) …
Authors
Yao Y; Lai R; Afkhami S; Haddadi S; Zganiacz A; Vahedi F; Ashkar AA; Kaushic C; Jeyanathan M; Xing Z
Journal
The Journal of Infectious Diseases, Vol. 216, No. 1, pp. 135–145
Publisher
Oxford University Press (OUP)
Publication Date
July 1, 2017
DOI
10.1093/infdis/jix252
ISSN
0022-1899