Journal article
BMP Receptor ALK3 Controls Collecting System Development
Abstract
The molecular signals that regulate growth and branching of the ureteric bud during formation of the renal collecting system are largely undefined. Members of the bone morphogenetic protein (BMP) family signal through the type I BMP receptor ALK3 to inhibit ureteric bud and collecting duct cell morphogenesis in vitro. We investigated the function of the BMP signaling pathway in vivo by generating a murine model of ALK3 deficiency restricted to …
Authors
Hartwig S; Bridgewater D; Di Giovanni V; Cain J; Mishina Y; Rosenblum ND
Journal
Journal of the American Society of Nephrology, Vol. 19, No. 1, pp. 117–124
Publisher
Wolters Kluwer
Publication Date
January 2008
DOI
10.1681/asn.2007010080
ISSN
1046-6673