Journal article
Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice
Abstract
We investigated the effects of estrogens on glucose homeostasis using the Aromatase Knockout (ArKO) mouse, which is unable to convert androgens into estrogens. The ArKO mouse is a model of total estrogen ablation which develops symptoms of metabolic syndrome. To determine the development and progression of whole body state of insulin resistance of ArKO mice, comprehensive whole body tolerance tests were performed on WT, ArKO and estrogen …
Authors
Van Sinderen M; Steinberg G; Jorgensen SB; Honeyman J; Chow JDY; Simpson ER; Jones MEE; Boon WC
Journal
The Journal of Steroid Biochemistry and Molecular Biology, Vol. 170, , pp. 39–48
Publisher
Elsevier
Publication Date
6 2017
DOI
10.1016/j.jsbmb.2016.05.013
ISSN
0960-0760