Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice Journal Articles

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abstract

Key Points Nbeal2 −/− mice are a model of human GPS, characterized by macrothrombocytopenia and α-granule-deficient platelets. NBEAL2 is required for normal platelet function and megakaryocyte development.

authors

Kahr, Walter HA
Lo, Richard W
Li, Ling
Pluthero, Fred G
Christensen, Hilary
Ni, Ran
Vaezzadeh, Nima
Hawkins, Cynthia E
Weyrich, Andrew S
Di Paola, Jorge
Landolt-Marticorena, Carolina
Gross, Peter Lawrence

status

published

publication date

November 7, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Blood Platelets (MeSH)
Blood Proteins (MeSH)
Bone Marrow (MeSH)
Carrier Proteins (MeSH)
Cell Differentiation (MeSH)
Cytoplasmic Granules (MeSH)
Disease Models, Animal (MeSH)
Female (MeSH)
Gene Expression (MeSH)
Gray Platelet Syndrome (MeSH)
Immunology (Science Metrix)
Male (MeSH)
Megakaryocytes (MeSH)
Mice (MeSH)
Mice, Knockout (MeSH)
P-Selectin (MeSH)
Platelet Aggregation (MeSH)
Platelet Factor 4 (MeSH)
Protein Isoforms (MeSH)
Thrombospondin 1 (MeSH)
von Willebrand Factor (MeSH)

published in

Blood Journal