Journal article
NOD1 Activators Link Innate Immunity to Insulin Resistance
Abstract
OBJECTIVE: Insulin resistance associates with chronic inflammation, and participatory elements of the immune system are emerging. We hypothesized that bacterial elements acting on distinct intracellular pattern recognition receptors of the innate immune system, such as bacterial peptidoglycan (PGN) acting on nucleotide oligomerization domain (NOD) proteins, contribute to insulin resistance.
RESEARCH DESIGN AND METHODS: Metabolic and …
Authors
Schertzer JD; Tamrakar AK; Magalhães JG; Pereira S; Bilan PJ; Fullerton MD; Liu Z; Steinberg GR; Giacca A; Philpott DJ
Journal
Diabetes, Vol. 60, No. 9, pp. 2206–2215
Publisher
American Diabetes Association
Publication Date
September 1, 2011
DOI
10.2337/db11-0004
ISSN
0012-1797