Journal article
Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis
Abstract
BACKGROUND: Depression is common in patients with inflammatory bowel disease (IBD) but the pathway is not well understood. We examined whether the locus of susceptibility to colitis in mice with depression-like behavior (DLB) resides with the macrophage and implicates the vagus nerve.
METHODS: Chronic colitis mimicking ulcerative colitis (UC) was induced by dextran sulfate sodium administered to C57BL/6-mice. Depression was induced by …
Authors
Ghia J-E; Park AJ; Blennerhassett P; Khan WI; Collins SM
Journal
Inflammatory Bowel Diseases, Vol. 17, No. 7, pp. 1474–1489
Publisher
Oxford University Press (OUP)
Publication Date
July 2011
DOI
10.1002/ibd.21531
ISSN
1078-0998
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adoptive TransferAnimalsAntidepressive AgentsBlotting, WesternC-Reactive ProteinColitis, UlcerativeDepressive DisorderDextran SulfateDisease Models, AnimalDisease SusceptibilityEnzyme-Linked Immunosorbent AssayHumansImmunoenzyme TechniquesInflammationInflammation MediatorsMacrophage Colony-Stimulating FactorMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, KnockoutParasympathetic Nervous SystemVagotomyVagus Nerve