Journal article
Lens-Specific Expression of TGF-β Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3
Abstract
PURPOSE: Smad3, a mediator of TGF-beta signaling has been shown to be involved in the epithelial-to-mesenchymal transformation (EMT) of lens epithelial cells in a lens injury model. In this study, the role of Smad3 in anterior subcapsular cataract (ASC) formation was investigated in a transgenic TGF-beta/Smad3 knockout mouse model.
METHODS: TGF-beta1 transgenic mice (containing a human TGF-beta1 cDNA construct expressed under the …
Authors
Banh A; Deschamps PA; Gauldie J; Overbeek PA; Sivak JG; West-Mays JA
Journal
Investigative Ophthalmology & Visual Science, Vol. 47, No. 8, pp. 3450–3460
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
August 1, 2006
DOI
10.1167/iovs.05-1208
ISSN
0146-0404
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsApoptosisBlotting, WesternCataractCollagen Type IVFibronectinsFluorescent Antibody Technique, IndirectGene Expression RegulationGenotypeIn Situ Nick-End LabelingLens Capsule, CrystallineLens, CrystallineMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicSmad3 ProteinTransforming Growth Factor betaTransforming Growth Factor beta1