Journal article
Homer modulates NFAT-dependent signaling during muscle differentiation
Abstract
While changes in intracellular calcium are well known to influence muscle contraction through excitation contraction coupling, little is understood of the calcium signaling events regulating gene expression through the calcineurin/NFAT pathway in muscle. Here, we demonstrate that Ca(+2) released via the inositol trisphosphate receptor (IP3R) increases nuclear entry of NFAT in undifferentiated skeletal myoblasts, but the IP3R Ca(+2) pool in …
Authors
Stiber JA; Tabatabaei N; Hawkins AF; Hawke T; Worley PF; Williams RS; Rosenberg P
Journal
Developmental Biology, Vol. 287, No. 2, pp. 213–224
Publisher
Elsevier
Publication Date
November 2005
DOI
10.1016/j.ydbio.2005.06.030
ISSN
0012-1606
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Active Transport, Cell NucleusAnimalsAnimals, NewbornCaffeineCalciumCalcium ChannelsCalcium SignalingCarrier ProteinsCell DifferentiationCell NucleusCells, CulturedEmbryo, MammalianHomer Scaffolding ProteinsInositol 1,4,5-Trisphosphate ReceptorsMiceMice, KnockoutMuscle Fibers, SkeletalMuscle, SkeletalMyoblastsNFATC Transcription FactorsReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release Channel