Journal article
Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture
Abstract
BackgroundThe LAR family Protein Tyrosine Phosphatase sigma (PTPσ) has been implicated in neuroendocrine and neuronal development, and shows strong expression in specific regions within the CNS, including the subventricular zone (SVZ). We established neural stem cell cultures, grown as neurospheres, from the SVZ of PTPσ knockout mice and sibling controls to determine if PTPσ influences the generation and the phenotype of the neuronal, astrocyte …
Authors
Kirkham DL; Pacey LK; Axford MM; Siu R; Rotin D; Doering LC
Journal
BMC Neuroscience, Vol. 7, No. 1,
Publisher
Springer Nature
Publication Date
December 2006
DOI
10.1186/1471-2202-7-50
ISSN
1471-2202