Journal article
Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice
Abstract
BACKGROUND: A causal relation between hyperhomocysteinemia (HHcy) and accelerated atherosclerosis has been established in apolipoprotein E-deficient (apoE-/-) mice. Although several cellular stress mechanisms have been proposed to explain the atherogenic effects of HHcy, including oxidative stress, endoplasmic reticulum (ER) stress, and inflammation, their association with atherogenesis has not been completely elucidated.
METHODS AND RESULTS: …
Authors
Zhou J; Werstuck GH; Lhoták S; de Koning ABL; Sood SK; Hossain GS; Møller J; Ritskes-Hoitinga M; Falk E; Dayal S
Journal
Circulation, Vol. 110, No. 2, pp. 207–213
Publisher
Wolters Kluwer
Publication Date
July 13, 2004
DOI
10.1161/01.cir.0000134487.51510.97
ISSN
0009-7322
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAortic DiseasesApolipoproteins EArteriosclerosisCarotid Artery DiseasesCollagenDisease ProgressionEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPFemaleFibrosisFoam CellsHSP47 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHeat-Shock ProteinsHypercholesterolemiaHyperhomocysteinemiaI-kappa B ProteinsLipidsMembrane ProteinsMiceMice, KnockoutModels, BiologicalMolecular ChaperonesNF-KappaB Inhibitor alphaOxidative StressPhosphorylationProtein FoldingProtein Processing, Post-TranslationalSerpinsStress, PhysiologicaleIF-2 Kinase