Journal article
Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis
Abstract
The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles. SR-BI is abundantly expressed in several tissues, including the liver, where its expression is …
Authors
Trigatti BL; Krieger M; Rigotti A
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 23, No. 10, pp. 1732–1738
Publisher
Wolters Kluwer
Publication Date
October 2003
DOI
10.1161/01.atv.0000091363.28501.84
ISSN
1079-5642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsArteriosclerosisBiological TransportCD36 AntigensCarrier ProteinsCells, CulturedCholesterolGene Expression RegulationHeart DiseasesLipoproteinsLipoproteins, HDLLiverMembrane ProteinsMiceMice, KnockoutProtein BindingRNA-Binding ProteinsReceptors, ImmunologicReceptors, LipoproteinReceptors, ScavengerScavenger Receptors, Class B