Journal article
Identification of periplakin as a major regulator of lung injury and repair in mice
Abstract
Periplakin is a component of the desmosomes that acts as a cytolinker between intermediate filament scaffolding and the desmosomal plaque. Periplakin is strongly expressed by epithelial cells in the lung and is a target antigen for autoimmunity in idiopathic pulmonary fibrosis. The aim of this study was to determine the role of periplakin during lung injury and remodeling in a mouse model of lung fibrosis induced by bleomycin. We found that …
Authors
Besnard V; Dagher R; Madjer T; Joannes A; Jaillet M; Kolb M; Bonniaud P; Murray LA; Sleeman MA; Crestani B
Journal
JCI Insight, Vol. 3, No. 5,
Publisher
American Society for Clinical Investigation
Publication Date
March 8, 2018
DOI
10.1172/jci.insight.90163
ISSN
2379-3708