Journal article
Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance
Abstract
In this study, we investigated the impact of cigarette smoke on tumor immune surveillance and its consequences to lung tumor burden in a murine lung metastasis model. Cigarette smoke exposure significantly increased the numbers of lung metastases following B16-MO5 melanoma challenge. This effect was reversible; we observed significantly fewer tumor nodules following smoking cessation. Using RAG2(-/-) and RAG2(-/-)gamma(c)(-/-) mice, we provide …
Authors
Lu L-M; Zavitz CCJ; Chen B; Kianpour S; Wan Y; Stämpfli MR
Journal
The Journal of Immunology, Vol. 178, No. 2, pp. 936–943
Publisher
Oxford University Press (OUP)
Publication Date
January 15, 2007
DOI
10.4049/jimmunol.178.2.936
ISSN
0022-1767