Journal article
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression
Abstract
IL-17 is the founding member of a novel family of proinflammatory cytokines that defines a new class of CD4+ effector T cells, termed "Th17." Mounting evidence suggests that IL-17 and Th17 cells cause pathology in autoimmunity, but little is known about mechanisms of IL-17RA signaling. IL-17 through its receptor (IL-17RA) activates genes typical of innate immune cytokines, such as TNFalpha and IL-1beta, despite minimal sequence similarity in …
Authors
Maitra A; Shen F; Hanel W; Mossman K; Tocker J; Swart D; Gaffen SL
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 18, pp. 7506–7511
Publisher
Proceedings of the National Academy of Sciences
Publication Date
5 2007
DOI
10.1073/pnas.0611589104
ISSN
0027-8424