Scholarly Works

Etv4 and Etv5 are required downstream of GDNF and...

Journal article

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

Abstract

Frank Costantini and colleagues report the identification of the ETS transcription factors, Etv4 and Etv5, as key targets of Ret signaling during kidney branching morphogenesis. Loss of Etv4 and Etv5 function in mice leads to complete failure of kidney development.

Authors

Lu BC; Cebrian C; Chi X; Kuure S; Kuo R; Bates CM; Arber S; Hassell J; MacNeil L; Hoshi M

Journal

Nature Genetics, Vol. 41, No. 12, pp. 1295–1302

Publisher

Springer Nature

Publication Date

December 1, 2009

DOI

10.1038/ng.476

ISSN

1061-4036

Associated Experts

John Algernon Hassell

Professor Emeritus, Faculty of Health Sciences

Lesley MacNeil

Associate Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

31 Biological Sciences 3102 Bioinformatics and computational biology 3105 Genetics 3001 Agricultural biotechnology

Medical Subject Headings (MeSH)

Animals Animals, Newborn DNA-Binding Proteins Glial Cell Line-Derived Neurotrophic Factor Kidney Mice Mice, Knockout Morphogenesis Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-ret Transcription Factors

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