Journal article
The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice
Abstract
OBJECTIVE: Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death. Here, we examine effects of SR-BI deficiency on cardiovascular phenotypes in low-density lipoprotein receptor (LDLR) knockout mice fed different …
Authors
Fuller M; Dadoo O; Serkis V; Abutouk D; MacDonald M; Dhingani N; Macri J; Igdoura SA; Trigatti BL
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 34, No. 11, pp. 2394–2403
Publisher
Wolters Kluwer
Publication Date
November 2014
DOI
10.1161/atvbaha.114.304200
ISSN
1079-5642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsArterial Occlusive DiseasesCholatesCholesterol, DietaryCoronary Artery DiseaseCytokinesDiet, AtherogenicDisease Models, AnimalEndothelium, VascularIncidenceIntercellular Adhesion Molecule-1MiceMice, KnockoutMyocardial InfarctionReceptors, LDLRisk FactorsScavenger Receptors, Class BVascular Cell Adhesion Molecule-1