Journal article
Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling
Abstract
Previously, we showed an inverse correlation between HSP27 serum levels and experimental atherogenesis in ApoE(-/-) mice that over-express HSP27 and speculated that the apparent binding of HSP27 to scavenger receptor-A (SR-A) was of mechanistic importance in attenuating foam cell formation. However, the nature and importance of the interplay between HSP27 and SR-A in atheroprotection remained unclear. Treatment of THP-1 macrophages with …
Authors
Raizman JE; Chen Y-X; Seibert T; Hibbert B; Cuerrier CM; Salari S; Zhao X; Hu T; Shi C; Ma X
Journal
Biochimica et Biophysica Acta, Vol. 1831, No. 12, pp. 1721–1728
Publisher
Elsevier
Publication Date
December 2013
DOI
10.1016/j.bbalip.2013.07.015
ISSN
0006-3002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAortaApolipoproteins EAtherosclerosisCHO CellsCell LineCricetulusDiet, High-FatDisease Models, AnimalFemaleFoam CellsGene Expression RegulationHSP27 Heat-Shock ProteinsHeat-Shock ProteinsHumansMiceMice, KnockoutMolecular ChaperonesNF-kappa BNeoplasm ProteinsNitrilesScavenger Receptors, Class ASignal TransductionSulfones