Journal article
The complement factor C5a receptor is upregulated in NFL−/− mouse motor neurons
Abstract
In NFL-/- mice, a model of motor neuron degeneration in ALS, degenerating spinal motor neurons express high levels of the receptor for the C5a anaphylatoxin (C5aR) early in the disease process. C5a is a potent in vitro neurotoxin for both Neuro2A and NGF-differentiated PC12 cells. While no interaction was observed between glutamate and C5a, both C5a and kainate upregulated the expression of activated C5aR. C5aR expression was increased in motor …
Authors
Humayun S; Gohar M; Volkening K; Moisse K; Leystra-Lantz C; Mepham J; McLean J; Strong MJ
Journal
Journal of Neuroimmunology, Vol. 210, No. 1-2, pp. 52–62
Publisher
Elsevier
Publication Date
May 2009
DOI
10.1016/j.jneuroim.2009.01.028
ISSN
0165-5728