Journal article
Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
Abstract
OBJECTIVE: Recent evidence has suggested that AHNAK expression is altered in obesity, although its role in adipose tissue development remains unclear. The objective of this study was to determine the molecular mechanism by which Ahnak influences adipogenesis and glucose homeostasis.
DESIGN: We investigated the in vitro role of AHNAK in adipogenesis using adipose-derived mesenchymal stem cells (ADSCs) and C3H10T1/2 cells. AHNAK-KO male mice were …
Authors
Shin JH; Kim IY; Kim YN; Shin SM; Roh KJ; Lee SH; Sohn M; Cho SY; Lee SH; Ko C-Y
Journal
PLOS ONE, Vol. 10, No. 10,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0139720
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3T3 CellsAdipocytesAdipogenesisAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsBody CompositionCell DifferentiationDiet, High-FatEnergy MetabolismGene Expression RegulationGlucoseGlucose Tolerance TestHomeostasisInsulinInsulin ResistanceMaleMembrane ProteinsMesenchymal Stem CellsMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMice, TransgenicNeoplasm ProteinsObesitySmad1 ProteinThermogenesis