Journal article
Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod‐induced psoriasis‐like inflammation
Abstract
Oncostatin M (OSM) has been reported to be overexpressed in psoriasis skin lesions and to exert proinflammatory effects in vitro on human keratinocytes. Here, we report the proinflammatory role of OSM in vivo in a mouse model of skin inflammation induced by intradermal injection of murine OSM-encoding adenovirus (AdOSM) and compare with that induced by IL-6 injection. Here, we show that OSM potently regulates the expression of genes involved in …
Authors
Pohin M; Guesdon W; Mekouo AAT; Rabeony H; Paris I; Atanassov H; Favot L; Mcheik J; Bernard F; Richards CD
Journal
European Journal of Immunology, Vol. 46, No. 7, pp. 1737–1751
Publisher
Wiley
Publication Date
July 2016
DOI
10.1002/eji.201546216
ISSN
0014-2980