Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice Journal Articles uri icon

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  • AbstractThe aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc–Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.


  • He, Wenqian
  • Chen, Chi-Jene
  • Mullarkey, Caitlin
  • Hamilton, Jennifer R
  • Wong, Christine K
  • Leon, Paul E
  • Uccellini, Melissa B
  • Chromikova, Veronika
  • Henry, Carole
  • Hoffman, Kevin W
  • Lim, Jean K
  • Wilson, Patrick C
  • Miller, Matthew S
  • Krammer, Florian
  • Palese, Peter
  • Tan, Gene S

publication date

  • October 10, 2017

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