Journal article
TGF-β receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
Abstract
Transforming growth factor (TGF)-beta signalling plays important roles in regulating lung development. However, the specific regulatory functions of TGF-beta signalling in developing lung epithelial versus mesenchymal cells are still unknown. By immunostaining, the expression pattern of the TGF-beta type II receptor (TbetaRII) was first determined in the developing mouse lung. The functions of TbetaRII in developing lung were then determined by …
Authors
Chen H; Zhuang F; Liu Y-H; Xu B; del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D
Journal
European Respiratory Journal, Vol. 32, No. 2, pp. 285–295
Publisher
European Respiratory Society (ERS)
Publication Date
August 2008
DOI
10.1183/09031936.00165407
ISSN
0903-1936
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCell ProliferationEpithelial CellsEpitheliumGene Expression Regulation, EnzymologicLungMesodermMiceMice, KnockoutModels, BiologicalProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaRespiratory MucosaSignal TransductionTime Factors