Journal article
Interleukin-13–Dependent Expression of Matrix Metalloproteinase-12 Is Required for the Development of Airway Eosinophilia in Mice
Abstract
We investigated the expression and function of matrix metalloproteinase-12 (MMP-12) in a model of allergic airway inflammation. Mice were sensitized mucosally by exposure to aerosolized ovalbumin (OVA) daily over a period of 10 d in the context of adenovirus-mediated granulocyte macrophage colony-stimulating factor (GM-CSF) expression. The ensuing inflammatory response is characterized by a Th2 cytokine profile, OVA-specific IgE, and airway …
Authors
Pouladi MA; Robbins CS; Swirski FK; Cundall M; McKenzie ANJ; Jordana M; Shapiro SD; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 30, No. 1, pp. 84–90
Publisher
American Thoracic Society
Publication Date
January 2004
DOI
10.1165/rcmb.2003-0051oc
ISSN
1044-1549