Journal article
Role of B Cells in Mucosal Vaccine–Induced Protective CD8 + T Cell Immunity against Pulmonary Tuberculosis
Abstract
Emerging evidence suggests a role of B cells in host defense against primary pulmonary tuberculosis (TB). However, the role of B cells in TB vaccine-induced protective T cell immunity still remains unknown. Using a viral-vectored model TB vaccine and a number of experimental approaches, we have investigated the role of B cells in respiratory mucosal vaccine-induced T cell responses and protection against pulmonary TB. We found that respiratory …
Authors
Khera AK; Afkhami S; Lai R; Jeyanathan M; Zganiacz A; Mandur T; Hammill J; Damjanovic D; Xing Z
Journal
The Journal of Immunology, Vol. 195, No. 6, pp. 2900–2907
Publisher
Oxford University Press (OUP)
Publication Date
September 15, 2015
DOI
10.4049/jimmunol.1500981
ISSN
0022-1767