Journal article
Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression
Abstract
We investigate the association of MUC1 with castration-resistant prostate cancer (CRPC), bone metastasis, and PC recurrence. MUC1 expression was studied in patient-derived bone metastasis and CRPCs produced by prostate-specific PTEN-/- mice and LNCaP xenografts. Elevations in MUC1 expression occur in CRPC. Among nine patients with hormone-naïve bone metastasis, eight express MUC1 in 61% to 100% of PC cells. Utilizing cBioPortal PC genomic data, …
Authors
Lin X; Gu Y; Kapoor A; Wei F; Aziz T; Ojo D; Jiang Y; Bonert M; Shayegan B; Yang H
Journal
Neoplasia, Vol. 19, No. 11, pp. 857–867
Publisher
Elsevier
Publication Date
November 2017
DOI
10.1016/j.neo.2017.06.006
ISSN
1522-8002