Journal article
Innate Immune Processes Are Sufficient for Driving Cigarette Smoke–Induced Inflammation in Mice
Abstract
The objective of this study was to characterize the impact of cigarette smoke exposure on lung immune and inflammatory processes. BALB/c and C57BL/6 mice were exposed to cigarette smoke for 4 days (acute) or at least 5 weeks (prolonged). Both mouse strains manifested an inflammatory response after acute smoke exposure, characterized by an influx of neutrophils and mononuclear cells. Multiplex analysis revealed a greater than twofold increase of …
Authors
Botelho FM; Gaschler GJ; Kianpour S; Zavitz CCJ; Trimble NJ; Nikota JK; Bauer CMT; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 42, No. 4, pp. 394–403
Publisher
American Thoracic Society
Publication Date
April 2010
DOI
10.1165/rcmb.2008-0301oc
ISSN
1044-1549