Journal article
Diacylglycerol Kinase Delta Promotes Lipogenesis
Abstract
We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in the expression of DGKδ during the differentiation of 3T3-L1 cells to adipocytes, as well as in the synthesis of neutral and polar lipids. When 3T3-L1 undifferentiated fibroblasts are transfected to express DGKδ, there is increased triglyceride synthesis without differentiation to adipocytes. Hence, expression of DGKδ …
Authors
Shulga YV; Loukov D; Ivanova PT; Milne SB; Myers DS; Hatch GM; Umeh G; Jalan D; Fullerton MD; Steinberg GR
Journal
Biochemistry, Vol. 52, No. 44, pp. 7766–7776
Publisher
American Chemical Society (ACS)
Publication Date
November 5, 2013
DOI
10.1021/bi401178y
ISSN
0006-2960