Journal article
Sex-Specific Differences in an ApoE −/−:Ins2 +/Akita Mouse Model of Accelerated Atherosclerosis
Abstract
Diabetic patients have a twofold to fourfold increased risk of cardiovascular disease. Despite a vast amount of research, the underlying mechanisms that predispose individuals with diabetes to the development of cardiovascular disease are unclear. To further our understanding of how diabetes promotes atherosclerosis, we have established, characterized, and manipulated a new model of hyperglycemia-induced atherosclerosis: the apolipoprotein …
Authors
Venegas-Pino DE; Wang P-W; Stoute HK; Singh-Pickersgill NA; Hong BY; Khan MI; Shi Y; Werstuck GH
Journal
American Journal Of Pathology, Vol. 186, No. 1, pp. 67–77
Publisher
Elsevier
Publication Date
January 2016
DOI
10.1016/j.ajpath.2015.09.009
ISSN
0002-9440