Journal article
The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses
Abstract
We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild-type mice in conditions in which T helper cells differentiated toward type 1 (TH1) rather than type 2 (TH2). B7-H3 expression was consistently …
Authors
Suh W-K; Gajewska BU; Okada H; Gronski MA; Bertram EM; Dawicki W; Duncan GS; Bukczynski J; Plyte S; Elia A
Journal
Nature Immunology, Vol. 4, No. 9, pp. 899–906
Publisher
Springer Nature
Publication Date
September 2003
DOI
10.1038/ni967
ISSN
1529-2908
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAutoantibodiesB7 AntigensB7-1 AntigenDendritic CellsDown-RegulationEncephalomyelitis, Autoimmune, ExperimentalFlow CytometryInterferon-gammaInterleukin-4Lymphocyte ActivationLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutOrthomyxoviridaeReceptors, Antigen, T-CellTh1 CellsVesicular stomatitis Indiana virus