The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses Academic Article uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild-type mice in conditions in which T helper cells differentiated toward type 1 (T(H)1) rather than type 2 (T(H)2). B7-H3 expression was consistently enhanced by interferon-gamma but suppressed by interleukin 4 in dendritic cells. B7-H3-deficient mice developed experimental autoimmune encephalomyelitis several days earlier than their wild-type littermates, and accumulated higher concentrations of autoantibodies to DNA. Thus, B7-H3 is a negative regulator that preferentially affects T(H)1 responses.


  • Suh, Woong-Kyung
  • Gajewska, Beata U
  • Okada, Hitoshi
  • Gronski, Matthew A
  • Bertram, Edward M
  • Dawicki, Wojciech
  • Duncan, Gordon S
  • Bukczynski, Jacob
  • Plyte, Suzanne
  • Elia, Andrew
  • Wakeham, Andrew
  • Itie, Annick
  • Chung, Stephen
  • Da Costa, Joan
  • Arya, Sudha
  • Horan, Tom
  • Campbell, Pauline
  • Gaida, Kevin
  • Ohashi, Pamela S
  • Watts, Tania H
  • Yoshinaga, Steven K
  • Bray, Mark R
  • Jordana, Manel
  • Mak, Tak W

publication date

  • September 2003

has subject area