Developmental regulation of O2 sensing in neonatal adrenal chromaffin cells from wild-type and NADPH-oxidase-deficient mice

Abstract. In mammals, adrenomedullary chromaffin cells (AMC) express a neutrophil-like NADPH oxidase and secrete catecholamines, which play a vital role in the ability of the neonate to survive hypoxic stress. To test whether NADPH oxidase functions as an O2 sensor, and whether mouse AMC express a developmentally regulated O2-sensing mechanism similar to rats, we compared the effects of hypoxia on cultured AMC from wild-type (WT) and transgenic …