Type I interferon restricts type 2 immunopathology...

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

Abstract

Dysregulation of group 2 innate lymphoid cells has been linked to virus-induced asthma. Fritz and colleagues demonstrate that deficiency in signaling via type I interferons in these cells can lead to dysregulated type 2 immunity during respiratory viral infection.

Authors

Duerr CU; McCarthy CDA; Mindt BC; Rubio M; Meli AP; Pothlichet J; Eva MM; Gauchat J-F; Qureshi ST; Mazer BD

Journal

Nature Immunology, Vol. 17, No. 1, pp. 65–75

Publisher

Springer Nature

Publication Date

January 1, 2016

DOI

10.1038/ni.3308

ISSN

1529-2908

Associated Experts

Karen Mossman

Professor, FHSMED

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