Journal article
Adaptive immune responses fail to provide protection against genital HSV‐2 infection in the absence of IL‐15
Abstract
IL-15 plays a crucial role in innate defense against viral infections. The role of IL-15 in the generation and function of adaptive immunity, following mucosal immunization, against genital HSV-2 has not been studied. Here, we report that immunized IL-15(-/-) mice were able to generate antibody and T cell-mediated immune responses against HSV-2, comparable to those seen in immunized B6 mice. However, immunized IL-15(-/-) mice were not protected …
Authors
Gill N; Ashkar AA
Journal
European Journal of Immunology, Vol. 37, No. 9, pp. 2529–2538
Publisher
Wiley
Publication Date
September 2007
DOI
10.1002/eji.200636997
ISSN
0014-2980