Journal article
Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase CROSS-TALK BETWEEN INTEGRATED STRESS RESPONSE AND THIOL METABOLISM*
Abstract
The integrated stress response mediated by eukaryotic translation initiation factor 2α (eIF2α) phosphorylation maintains cellular homeostasis under endoplasmic reticulum (ER) stress. eIF2α phosphorylation induces activating transcription factor 4 (ATF4), a basic leucine zipper transcription factor that regulates the expression of genes responsible for amino acid metabolism, cellular redox state, and anti-stress responses. Cystathionine γ-lyase …
Authors
Dickhout JG; Carlisle RE; Jerome DE; Mohammed-Ali Z; Jiang H; Yang G; Mani S; Garg SK; Banerjee R; Kaufman RJ
Journal
Journal of Biological Chemistry, Vol. 287, No. 10, pp. 7603–7614
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1074/jbc.m111.304576
ISSN
0021-9258