Journal article
AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue
Abstract
The effects of small-molecule AMP-activated protein kinase (AMPK) activators in rat epididymal adipocytes were compared. SC4 was the most effective and submaximal doses of SC4 and 5-amino-4-imidazolecarboxamide (AICA) riboside were combined to study the effects of AMPK activation in white adipose tissue (WAT). Incubation of rat adipocytes with SC4 + AICA riboside inhibited noradrenaline-induced lipolysis and decreased hormone-sensitive lipase …
Authors
Chuang S-J; Johanns M; Ruys SPD; Steinberg GR; Kemp BE; Viollet B; Rider MH
Journal
Biochemical Journal, Vol. 478, No. 21, pp. 3869–3889
Publisher
Portland Press
Publication Date
November 12, 2021
DOI
10.1042/bcj20210411
ISSN
0264-6021