Journal article
Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis
Abstract
BACKGROUND: Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) in the cardiovascular system. The deficiency of CSE in mice leads to a decreased endogenous H2S level, an age-dependent increase in blood pressure, and impaired endothelium-dependent vasorelaxation. To date, there is no direct evidence for a causative role of altered metabolism of endogenous H2S in atherosclerosis development.
METHODS AND RESULTS: Six-week-old CSE gene …
Authors
Mani S; Li H; Untereiner A; Wu L; Yang G; Austin RC; Dickhout JG; Lhoták Š; Meng QH; Wang R
Journal
Circulation, Vol. 127, No. 25, pp. 2523–2534
Publisher
Wolters Kluwer
Publication Date
June 25, 2013
DOI
10.1161/circulationaha.113.002208
ISSN
0009-7322