Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax Journal Articles

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abstract

tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL), like Mtch2, promotes the activating conformational change of tBid.

authors

Shamas-Din, Aisha
Bindner, Scott
Chi, Xiaoke
Leber, Brian
Andrews, David W
Fradin, Cecile

status

published

publication date

May 1, 2015

has subject area

03 Chemical Sciences (FoR)
06 Biological Sciences (FoR)
11 Medical and Health Sciences (FoR)
Animals (MeSH)
Apoptosis (MeSH)
Apoptosis Regulatory Proteins (MeSH)
BH3 Interacting Domain Death Agonist Protein (MeSH)
Bcl-2-Like Protein 11 (MeSH)
Biochemistry & Molecular Biology (Science Metrix)
Cardiolipins (MeSH)
Cholesterol (MeSH)
Humans (MeSH)
Liposomes (MeSH)
Membrane Lipids (MeSH)
Membrane Proteins (MeSH)
Mice (MeSH)
Mice, Knockout (MeSH)
Mitochondria, Liver (MeSH)
Mitochondrial Membranes (MeSH)
Models, Biological (MeSH)
Mutagenesis, Site-Directed (MeSH)
Permeability (MeSH)
Protein Conformation (MeSH)
Proto-Oncogene Proteins (MeSH)
Recombinant Proteins (MeSH)
bcl-2 Homologous Antagonist-Killer Protein (MeSH)
bcl-2-Associated X Protein (MeSH)

published in

Biochemical Journal Journal