Journal article
Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current
Abstract
RATIONALE: Baseline contractility of mouse hearts is modulated in a phosphatidylinositol 3-kinase-γ-dependent manner by type 4 phosphodiesterases (PDE4), which regulate cAMP levels within microdomains containing the sarcoplasmic reticulum (SR) calcium ATPase type 2a (SERCA2a).
OBJECTIVE: The goal of this study was to determine whether PDE4D regulates basal cardiac contractility.
Authors
Beca S; Helli PB; Simpson JA; Zhao D; Farman GP; Jones P; Tian X; Wilson LS; Ahmad F; Chen SRW
Journal
Circulation Research, Vol. 109, No. 9, pp. 1024–1030
Publisher
Wolters Kluwer
Publication Date
October 14, 2011
DOI
10.1161/circresaha.111.250464
ISSN
0009-7330
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCalciumCalcium Channels, L-TypeCalcium-Binding ProteinsCardiomyopathy, DilatedCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4FemaleHeart VentriclesHumansMaleMiceMice, KnockoutModels, AnimalMyocardial ContractionMyocytes, CardiacPhosphatidylinositol 3-KinasesRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPases