Journal article
Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy
Abstract
Angiotensin-converting enzyme (ACE) and ACE2 play a critical role in the renin-angiotensin system (RAS) by altering angiotensin II (ANGII) levels, thus governing its deleterious effects. Both enzymes are altered by sex and diabetes, and play an important role in the development of diabetic nephropathy (DN). Importantly, previous evidence in diabetic and ACE2-deficient (ACE2KO) males suggest a sex-dependent crosstalk between renal ACE and ACE2. …
Authors
Clotet-Freixas S; Soler MJ; Palau V; Anguiano L; Gimeno J; Konvalinka A; Pascual J; Riera M
Journal
Laboratory Investigation, Vol. 98, No. 9, pp. 1237–1249
Publisher
Elsevier
Publication Date
September 2018
DOI
10.1038/s41374-018-0084-x
ISSN
0023-6837