Journal article
Deleting Rac1 improves vertebral bone quality and resistance to fracture in a murine ovariectomy model
Abstract
The roles of Rac1 and Rac2 in regulating osteoclast-mediated bone quality in postmenopausal osteoporosis were evaluated using an ovariectomized murine model. Animals' bone composition and architecture were evaluated. Our results demonstrate that the deletion of Rac1 increases vertebral bone quality compared to wild-type bones in an ovariectomized model.IntroductionTo determine the roles of the Rho family small GTPases Rac1 and Rac2 in …
Authors
Magalhaes JKRS; Grynpas MD; Willett TL; Glogauer M
Journal
Osteoporosis International, Vol. 22, No. 5, pp. 1481–1492
Publisher
Springer Nature
Publication Date
5 2011
DOI
10.1007/s00198-010-1355-6
ISSN
0937-941X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Absorptiometry, PhotonAnimalsBone DensityDisease Models, AnimalFemaleFemurGene DeletionHumansLumbar VertebraeMiceMice, KnockoutNeuropeptidesOsteoporosis, PostmenopausalOsteoporotic FracturesOvariectomyStress, MechanicalX-Ray Microtomographyrac GTP-Binding Proteinsrac1 GTP-Binding ProteinRAC2 GTP-Binding Protein