Journal article
Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin
Abstract
RATIONALE: Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is characterised poorly.
OBJECTIVES: To assess the effect of Gram-positive bacterial infection on fibrosis exacerbation in mice.
Authors
Knippenberg S; Ueberberg B; Maus R; Bohling J; Ding N; Tarres MT; Hoymann H-G; Jonigk D; Izykowski N; Paton JC
Journal
Thorax, Vol. 70, No. 7,
Publisher
BMJ
Publication Date
July 1, 2015
DOI
10.1136/thoraxjnl-2014-206420
ISSN
0040-6376
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnti-Bacterial AgentsApoptosisBacterial ProteinsBronchoalveolar Lavage FluidDiphtheria ToxinDisease Models, AnimalDisease ProgressionEpithelial CellsFemaleMice, Inbred C57BLMice, KnockoutMice, TransgenicPneumococcal VaccinesPneumonia, PneumococcalPulmonary AlveoliPulmonary FibrosisStreptolysinsTransforming Growth Factor beta1