Loss of T cells influences sex differences in stress-related gene expression Academic Article uri icon

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abstract

  • Deficiencies in the adaptive immune system have been linked to anxiety-like behaviours and stress reactivity. Mice lacking T lymphocytes through knockout of the T cell receptor (TCR) β and δ chains were compared to wild type C57Bl/6 mice. Central stress circuitry gene expression was assessed following repeated restraint stress. TCRβ-/-δ-/- mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene expression after repeated restraint stress. Sexual dimorphic stress responses were observed in wild-type C57Bl/6 mice but not in TCRβ-/-δ-/- mice. These data suggest that T cell-brain interactions influence sex-differences in CNS stress circuitry and stress reactivity.

authors

  • Rilett, Kelly C
  • Luo, Owen D
  • McVey-Neufeld, Karen-Anne
  • MacKenzie, Robyn N
  • Foster, Jane

publication date

  • June 2020