Loss of T cells influences sex differences in stress-related gene expression

Deficiencies in the adaptive immune system have been linked to anxiety-like behaviours and stress reactivity. Mice lacking T lymphocytes through knockout of the T cell receptor (TCR) β and δ chains were compared to wild type C57Bl/6 mice. Central stress circuitry gene expression was assessed following repeated restraint stress. TCRβ-/-δ-/- mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene …