Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis Academic Article uri icon

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abstract

  • Salicylate at concentrations achievable through the intake of Aspirin or salsalate activates AMPK in prostate and lung cancer cells inhibiting their survival. Salicylate-induced inhibition of cell survival involves the blocking of denovo lipogenesis and is enhanced by clinical concentrations of metformin.

publication date

  • July 15, 2015

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